Radioprotective properties of myeloid-derived suppressor cells

Myeloid derived suppressor cells (MDSCs) are a heterogeneous group of bone marrow derived immature myeloid cells that are expanded in patients with cancer, infection, trauma, or autoimmune diseases (1). MDSC originate from a common myeloid progenitor cell and develop along two separate lineages, monocytic MDSC (M-MDSC) and granulocytic MDSC (G-MDSC), but never develop the characteristics of mature monocytes, macrophages, or neutrophils (1).