Information-dense analysis for information-dense understanding

Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen


Using mass cytometry coupled with cellular barcoding, Wong et al. (1) report a high-dimensional map of human T-cell trafficking receptors and cytokine profiles in several different tissues. Specifically, the authors analyzed T cells from eight human organs, including healthy donors and patients with different underlying conditions, with a range of three to five individual samples per organ. Perhaps unsurprisingly, their findings highlight the dynamic and complex nature of T cells in different organs and stress the importance of looking beyond peripheral blood when analyzing human T cell phenotype and function.