Mutant p53 talks to proteasomes—is there a feedback loop between Nrf2 and mutant p53?

The p53 protein is a powerful tumor suppressor, often termed as ‘guardian of the genome’, whose function is lost in many types of human cancers (1). The loss of function is impelled either by de-regulation of the E3 ubiquitin ligase, MDM2 protein (2) or by the TP53 gene mutations of missense type (3). Mutations in TP53 gene occur at very high frequency and range from 10% to 97% depending on the cancer type (4). Single amino acids substitutions result in the loss of tumor suppression transcription function, promote the change of the conformation and loss of sequence-specific DNA binding function of mutant p53 (mtp53) (5).