DDR1 and Notch: a multifaceted synergy

In recent years our appreciation of the function and design of many signalling pathways implicated in cancer has changed substantially. The original idea of intrinsically independent and linear routes has progressively evolved to the concept of complex networks, involving extensive crosstalk and interplay between various signalling pathways. Yet, we are only beginning to understand how these networks are interconnected within cancer cells. This knowledge will be essential for the design of effective drug combinations as well as for the anticipation of potential mechanisms of resistance.