Article Abstract

New insights into human testicular germ cell tumors: miR-223-3p gains oncogene function

Authors: Erika Di Zazzo, Bruno Moncharmont


Testicular germ cell tumors (TGCTs) are the most common malignancy in young males and represent the major cause of cancer death in 15 to 34 years old males. The majority of TGCTs originate from germ cells and are classified into seminoma and non-seminoma germ cell tumors (NSGCTs). Tumors with different cell components, e.g., seminoma and embryonic cell carcinoma, are generally indicated as mixed germ cell tumors.