Article Abstract

IL-10 and IL-10RB gene polymorphisms are correlated with hepatitis B-related hepatocellular carcinoma in the Chinese Han population

Authors: Jinxue Zhou, Weijia Liao, Yangjing Zhao, Yanhui Chen, Liling Qin, Henghui Zhang, Shuijun Zhang

Abstract

Background: Polymorphisms in the cytokine genes interleukin-10 (IL-10) and interleukin-10 receptor-B (IL-10RB) can influence immune responses and inflammation and affect the development of chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC).
Methods: We investigated the influence of three SNPs in IL-10 (rs3790622, rs1518110, rs1800872) and one SNP in IL-10RB (rs2244305) on the risk of developing HCC and clinical features of HCC. We determined the genotypes of 430 HCC patients, 342 CHB patients and 371 matched healthy donors by MALDI-TOF Mass Spectrometry.
Results: Our study showed that HCC patients had higher frequencies of the T allele at rs1518110 of the IL-10 gene, the A allele at rs1800872 of the IL-10 gene, and the C allele at rs2244305 of IL-10RB gene compared to both the CHB and healthy groups. Moreover, compared to both the CHB and healthy groups, the TT genotype at rs1518110, the AA genotype at rs1800872 and the CC genotype at rs2244305 showed high frequency in HCC patients. The difference of these SNPs genotype and allele frequencies between the CHB and healthy groups was not statistically significant. Stratified analysis indicated that both GG/GT genotypes at rs1518110 and CC/AC genotypes at rs1800872 were strongly correlated to smoking and an increased rate of tumor recurrence in HCC patients. The CC genotype of rs2244305 was linked to multiple tumor number, BCLC stage, and distant and lymph node metastasis in HCC. Our results indicated that IL-10 gene polymorphisms (rs1518110, rs1800872) and IL-10 gene polymorphisms (rs2244305) might be related to hepatitis B-related HCC in Han population of China. In particular, the GG/GT genotypes at rs1518110 and CC/AC genotypes at rs1800872 may contribute to the high incidence of tumor recurrence.
Conclusions: Our study indicates that functional IL-10 (rs1518110, rs1800872) and IL-10RB (rs2244305) polymorphisms may result in the risk of hepatitis B-related HCC in Han population of China.

Refbacks

  • There are currently no refbacks.