Article Abstract

Multiscale modeling of glioblastoma

Authors: Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Abstract

As reviewed in the Editorial “Targeting glioblastoma stem- cells: a recurrent challenge in neuro-oncology” (1), we recently developed a 3D mathematical model of glioblastoma multiforme (GBM) progression and response to therapy (2). The development of the model necessarily required assumptions to be made about which key biological processes to incorporate and which to exclude. We aimed to develop a model that extensively defined the main features of GBM, which, as described in the Editorial, include invasiveness, intense proliferation, necrosis and neovascularization, as well as the crosstalk among GBM cells and cells in the microenvironment, and to use this model to test the effectiveness of different anti-GBM treatment strategies available in the clinical practice.