Article Abstract

Editorial: fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

Authors: Sabrina P. Koh, Agadha C. Wickremesekera, Tinte Itinteang, Swee T. Tan


Glioblastoma (GB) is the most aggressive primary brain cancer of adulthood, associated with an average 5-year survival rate of 2% (1). A small population of tumor-initiating cells, termed cancer stem cells (CSCs), are the putative origin of GB, accounting for tumor development, progression and recurrence (2).