Article Abstract

Prognostic values of preoperative NLR and PLR in patients with laryngeal squamous cell carcinoma

Authors: Xiu-Ping Tu, Tian Tian, Liang-Si Chen, Xiao-Ning Luo, Zhong-Ming Lu, Si-Yi Zhang, Shao-Hua Chen


Background: This study was aimed to investigate the prognostic values of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in patients with laryngeal squamous cell carcinoma (LSCC).
Methods: Clinicopathologic records of 290 patients with LSCC were analyzed. The neutrophil, platelet, and lymphocyte counts of these patients were recorded before operation. NLR and PLR were calculated.
Results: NLR >2.22 or PLR >114 was considered to be elevated. Elevated NLR and PLR were more frequent in LSCC patients with advanced T stage than in those with early T stage. Patients with elevated NLR or PLR had shorter OS compared with those with decreased NLR or PLR. Furthermore, the combination of NLR and PLR was more sensitive than either one alone in predicting prognosis.
Conclusions: The preoperative NLR and PLR may be used as effective prognostic factors for LSCC patients, and the prognostic accuracy in prognosis prediction can be enhanced when they are used in combination.