Article Abstract

Prognostic value of LAMP1 in surgically resected esophageal squamous cell carcinoma

Authors: Wei Wang, Yujing Zhang, Yingze Xu, Xiaobei Zhang, Ming Ma, Guoan Zhang, Jian Huang

Abstract

Background: The 5-year survival rate of esophageal squamous cell carcinoma (ESCC) is very low. It has been confirmed that lysosomal associated membrane protein 1 (LAMP1) plays an important role in the invasion and metastasis of some tumors. Our previous study showed that the LAMP1 expression levels were significantly different between TNM stages and histological differentiation of ESCC.
Methods: We followed up the 584 ESCC patients enrolled in our previous study and analyzed the relationship between LAMP1 and patients’ outcome.
Results: Binary logistic regression analysis showed that the degrees of differentiation showed medium negative correlation with LAMP1 expression (ORdifferentiation =0.502, P<0.001). Kaplan-Meier survival curves indicated that patients with a higher LAMP1 expression level showed worse prognosis (P<0.05). The hazard plots showed that organ metastasis, high TNM classification, and high LAMP1 expression level were risk factors for survival in ESCC patients (P<0.05).
Conclusions: LAMP1 expression levels correlated with tumor histological differentiation and patient prognosis. High expression of LAMP1 predicts poor prognosis in ESCC patients.