Article Abstract

Prognostic factors and outcomes of osseous chondrosarcoma after surgery: the 2004–2014 Surveillance, Epidemiology, and End Results database study

Authors: Chun-Hui Chen, Dong Chen, Zhong-Ke Lin, Hui Xu, Jing-Wei Zheng, Yan Lin, Wen-Fei Ni, Xiang-Yang Wang, Hua Chen, Zhi-Guang Qiao, Ai-Min Wu

Abstract

Background: Chondrosarcoma is a major malignant tumor occurs at skeletal system, the prognostic factors and survival outcomes of osseous chondrosarcoma after surgery were still unclear.
Methods: The demographic information extracted include: age, gender, race, year of diagnosis, tumor sites, tumor size, grade, stages from the Surveillance, Epidemiology, and End Results (SEER) 18 registries research database [2004–2014]. The patients don’t perform the surgery or the tumors sited at extraskeletal tissue are excluded. Multivariable Cox proportional hazard regression models are used to calculate the HRs with 95% CIs for chondrosarcoma cancer-specific survival (CCSS).
Results: Total of 1,630 osseous chondrosarcoma patients that performed surgery are included in present study. Multivariable Cox proportional hazard regression models find that the higher grade and stage, old age more than 75 years, and tumor size more than 20 cm have significant associated with the CCSS. But the gender, race, and tumor sites have no significant associated with CCSS.
Conclusions: We find grade, stage were independent prognostic factors for survival rate of osseous chondrosarcoma after surgery, and higher age more than 75 years, bigger tumor size more than 20 cm is also predicted poor outcomes.