The urea cycle enzymes act as metabolic suppressors in clear cell renal cell carcinoma

Renal cell carcinoma (RCC) comprises about 3–4% of adult malignancies and according to recent estimates, over 65,000 new cases will be diagnosed in 2018 (3.8% of all new cancer cases), and nearly 15,000 patients will die of this tumor (2.5% of all cancer deaths) in the United States (1).