Article Abstract

Relationships of kin17 protein expression with clinical features and prognosis of colorectal cancer

Authors: Liqin Ruan, Qunguang Jiang, Haitao Zhang

Abstract

Background: To investigate the relationships of kin17 protein expression with the clinical features and prognosis of colorectal cancer (CRC).
Methods: The clinicopathological data and paraffin specimens of 135 CRC patients in the First Affiliated Hospital of Nanchang University from November 2008 to November 2009 were collected. Immunohistochemistry was used to detect the kin17 protein expression in paraffin-embedded specimens, and the relationship between the kin17 protein expression and the clinicopathological features and prognosis of CRC were analyzed.
Results: The kin17 protein expression was significantly higher in cancer tissue than in paracancerous tissue (49.6% vs. 14.8%, P<0.01). Of 135 CRC patients, the rate of positive kin17 protein expression was significantly higher in T1 + T2 stage than in T3 + T4 stage (31% vs. 60.6%, P<0.05), significantly lower in patients without lymph node metastasis than in those with lymph node metastasis (9.7% vs. 100%, P<0.01), and significantly higher in patients with distant metastasis than in those without distant metastasis (81.25% vs. 52.9%, P<0.05). Univariate survival analysis showed age, depth of tumor invasion, lymph node metastasis, distant metastasis, clinical stage, vascular invasion, perineural invasion, preoperative CEA value, preoperative CA199 value, and kin17 protein expression were significantly associated with the prognosis of CRC (all P<0.05). Multivariate survival/prognosis analysis showed that the kin17 protein expression, age, preoperative CEA value, lymph node metastasis, and distant metastasis were independent prognostic factors for CRC.
Conclusions: The kin17 protein expression is remarkably up-regulated in CRC tissue, and its expression level is related to the depth of tumor invasion, lymph node metastasis/distant metastasis, clinical stage, histological grade, and vascular invasion. Also, kin17 protein is an independent prognostic factor for CRC.