Effects of androgen deprivation therapy duration and Gleason grade on survival outcomes of high risk prostate cancer

Do Kyung Kim, Yon Hee Kim, Jae Heon Kim


Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. There are various types of PCa treatments like as surgery, radiotherapy, and hormone therapy. Many PCa patients receive androgen deprivation therapy (ADT) based on the hormone dependence of PCa. Recently, several studies have been conducted to establish the relationship between ADT and various complications (e.g., cardiovascular disease, stroke, Alzheimer’s disease, and osteoporosis). Most of them have reported a correlation between ADT and these complications, leading to an interest in proper duration of ADT. Consequently, several trials have been conducted to confirm this.