Article Abstract

Angiosarcoma of the breast, the unknown—a review of the current literature

Authors: Emanuela Esposito, Franca Avino, Raimondo di Giacomo, Ivana Donzelli, Ugo Marone, Maria Teresa Melucci, Chiara Rinaldo, Fulvio Ruffolo, Ruggero Saponara, Claudio Siani, Raffaele Tortoriello, Gerardo Botti, Massimo Rinaldo, Alfredo Fucito

Abstract

Angiosarcoma of the breast is one of the rarest malignancies. Breast angiosarcoma can be classified into primary when arising de novo and secondary to chronic lymphoedema or breast irradiation. Molecular pathways involved in angiosarcoma development have not been described clearly, yet some gene point mutations and protein altered expression levels have been detected. So far, their management is based above all on surgery. Hence, further studies starting from the few known key points may help to develop more effective strategies based both on target therapies, together with surgery.

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