Neoadjuvant chemotherapy for locally invasive cervical cancer in pregnancy: two case reports

Ming-Zhu Li, Yun Zhao, Yu-Ligh Liou, Xiao-Ping Li, Xiao-Hong Zhang, Yue Wang, Zhi-Qi Wang, Xiao-Lian Zhu, Jian-Liu Wang, Li-Hui Wei


Although cervical cancer is the most common gynecological cancer, it is rare in pregnant women. Treatment of locally invasive cervical cancer during pregnancy is often complex and challenging. Neoadjuvant chemotherapy (NACT) is a possible treatment option. Here we report two cases of cervical cancer diagnosed during pregnancy, one of which was sensitive to NACT, while the other was not sensitive to chemotherapy but showed a good response to concurrent chemoradiotherapy (CCRT) and intra-arterial chemotherapy. Both of these cases have not revealed any signs of tumor recurrence and their children are growing healthily.