New approaches to model glioblastoma in vitro using brain organoids: implications for precision oncology

Guillermo A. Gomez, Mariana Oksdath, Michael P. Brown, Lisa M. Ebert


Glioblastoma is an aggressive form of primary brain cancer for which new treatment approaches are desperately needed. To achieve this goal, better experimental approaches to study human glioblastoma are required; and in particular, methods that recapitulate the native tumor microenvironment will be most valuable. In accordance with this need, Howard Fine and co-workers have developed a new experimental model, termed GLICO (1), which should facilitate a better understanding of the biology of the disease, and importantly, enable more reliable testing of potential new therapies.