Vol 5, Supplement 4 (October 2016): Translational Cancer Research

Editorial

Liquid biopsy in non-small cell lung cancer: come of age
Myung-Ju Ahn
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Commentary on “A chimeric switch-receptor targeting PD1 augments the efficacy of second-generation CAR T cells in advanced solid tumors”
Richard A. Morgan
Is it useful to combine taxanes with targeted agents in mCRPC patients—have we hit the target in this phase II study with docetaxel and curcumin allowing going for a phase III study?
Elise Nassif, Constance Michel, Constance Thibault, Stéphane Oudard
Pathogenesis of acute gastroesophageal reflux disease might be changing
Naoya Yoshida, Yu Imamura, Yoshifumi Baba, Hideo Baba
Defining differential roles for microglia and infiltrating macrophages in the growth and neovascularization of glioma
Jeremy Tetsuo Miyauchi, Stella E. Tsirka
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Can combination chemotherapy be standard therapy for sensitive relapsed small-cell-lung cancer?
Jung Soo Kim, Jeong-Seon Ryu
Chemotherapy plus intercalated or continuous EGFR-TKI in advanced non-small cell lung cancer
Antonio Rossi
miRNA based signature for predicting epithelial ovarian cancer relapse-progression: a step forward to prime time clinical adoption?
Lorenzo Ceppi, Sergio Marchini, Robert Fruscio
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Pancreatic cancer immunotherapy: coming of age
Irfana Muqbil, Ramzi M. Mohammad
Glioblastoma: does PET shed light to a difficult problem?
Jason M. Johnson, Caroline Chung
Hypofractionation for postoperative breast cancer radiotherapy: is acute toxicity a limiting factor?
Marco Krengli, Salvatore Terrazzino, Letizia Deantonio
Hypofractionated radiotherapy for breast cancer: too fast or too much?
Vassilis E. Kouloulias, Anna G. Zygogianni
The addition of bevacizumab to neoadjuvant chemotherapy in HER2-negative inflammatory breast cancer, more not necessarily better
Humaid O. Al-Shamsi, Nuhad K. Ibrahim
Pancreatic cancer-derived exosomes: new role in paraneoplastic syndromes?
Chi Lam Au Yeung, Samuel C. Mok
What is the role of stereotactic body radiotherapy to treat inoperable hepatocellular carcinoma?
Susannah M. Cheek, David A. Geller
Radiofrequency ablation and stereotactic body radiotherapy as non-surgical options for hepatocellular carcinoma
Daniel Benjamin Gans, Sidhartha Tavri, Pablo Ros, Indravadan Patel
The potential of proteogenomics in oncology
Pamela Pinzani, Francesca Salvianti
Beyond genomics: biologic insights from the CPTAC proteogenomic analysis of breast cancer
Sandeep Rajput, Cynthia X. Ma
Intravenous and intraperitoneal paclitaxel with S-1: new hope for patients with pancreatic cancer and peritoneal metastases?
Willem Niesen, Oliver Strobel
Deciphering ZIC2/OCT4 signaling as a vulnerability in liver cancer stem cells
Stephanie Ma
Autophagy is required for PTEN-loss driven prostate cancer
David J. Barakat, Alan D. Friedman
Targeting pancreatic stellate cells to improve pancreatic cancer radiosensitivity
Vickna Balarajah, Cindy Neuzillet, Hemant M. Kocher
Resistance mechanisms in glioblastoma stem cells: finding opportunities in challenges
Tejpal Gupta
Shuttling towards a predictive assay for radiotherapy
Faissal Ouenzar, Michael J. Hendzel, Michael Weinfeld
Macrohistone H2A1 takes the center stage in cancer research as a regulator of stemness
Oriana Lo Re, Manlio Vinciguerra
Emerging role for USP1 in glioblastoma stem cell maintenance and radioresistance: a potential target for glioblastoma therapy
Quintino Giorgio D’Alessandris, Lucia Ricci-Vitiani
Exosomes containing adrenomedullin mediate new onset diabetes and weight loss in pancreatic cancer
Edward R. Sauter

Perspective

Role of the lncRNAs in malignant melanoma and their involvement in metastasis
Nejat Dalay
Apatinib for gastric cancer: are we moving the antiangiogenic strategy any forward?
Giuseppe Aprile, Marta Bonotto, Elena Ongaro, Silvio Ken Garattini, Valentina Fanotto, Debora Basile, Monica Cattaneo, Mariaelena Casagrande, Laura Ferrari, Giovanni Gerardo Cardellino, Paola Ermacora, Nicoletta Pella, Mariella Giovannoni, Gianpiero Fasola
Perspective on therapeutic application of selective internal radiotherapy in colorectal cancer liver metastasis
Mahdi Hussain Al Bandar, Nam Kyu Kim
A new fertility risk rating system for surgical, radiotherapy, and chemotherapy interventions used in testicular cancer
Jessica R. Walter, Mary E. Lohman, Shilajit D. Kundu, Shuai Xu
Glioblastoma stem cells differentiation through epigenetic modulation is driven by miR-296-5p/HMGA1/Sox2 axis
Veronica Ferrucci, Massimo Zollo
PIK3CA mutated, hormonal receptors and HER2: individual targets but partnered in the escape to targeted therapy in breast cancer
Joseph A. Pinto, Henry L. Gomez
Can we stop the progression of chronic liver disease to hepatocellular carcinoma?
Mark A. Feitelson
Genomic analysis of circulating tumor DNA to predict endocrine resistance and clonal evolution in patients with prostate cancer: Clinical perspectives and research opportunities
Dario Trapani, Giuseppe Curigliano
Emerging mutations and functional changes of androgen receptor associated with treatment resistance in prostate cancer
Filippo Martignano, Cristian Lolli, Giorgia Ravaglia, Valentina Gallà, Giorgia Gurioli, Samanta Salvi
New insights into patient radiosensitivity in relation to the biology of the ATM protein
David Murray, Razmik Mirzayans, Matthew Parliament
Is inhibiting the DNA damage response the answer to treatment resistance in glioma stem cells?
Patries M. Herst

Commentary

Diagnostic performance of [18F] fluorodeoxyglucose PET/CT and diffusion-weighted magnetic resonance imaging for the evaluation of treatment response to induction chemotherapy followed by definitive chemoradiotherapy in locally advanced head and neck squamous cell carcinoma
Jon Cacicedo, Arturo Navarro
Emerging molecular mechanisms underlying cancer metastasis: the rising role of the long non-coding RNA GAS5
Marianna Lucafò, Gabriele Stocco, Giuliana Decorti
A new angle on Notch combination therapies
Urban Lendahl
Intracranial activity of crizotinib: something to rely on?
Elizabeth Dudnik, Nir Peled
Selective FcγR engagement by human agonistic anti-CD40 antibodies
Peter Ellmark, Sara M. Mangsbo, Malin Lindstedt
New applications for deep sequencing of the T cell receptor repertoire in cancer patients
Alex H. Lee, Robert M. Prins
The prospective correlation between GGN and CAG repeat polymorphisms of androgen receptors and testicular cancer
Saima Shakil Malik, Nosheen Masood
The challenge for precision medicine: all tumor genomes are different and all cancer patients are different in their own way
Wei Cao, Fred G. Biddle, Hani Choudhry, Wei Wu
In vivo modeling of diffuse large B cell lymphoma (DLBCL) with the myeloid differentiation primary response gene 88 (MYD88) L265P mutationon
Vu N. Ngo
T cells exert force for pMHC pull-ups
Chenghao Ge, Muaz Nik Rushdi, Cheng Zhu
Perspective towards the clinical application of eribulin in soft tissue sarcomas
Piotr Rutkowski, Iwona Lugowska
Risk stratification in prostate cancer treated with radiation therapy: a window of opportunity for new clinical trials
Manuel Conson, Laura Cella, Roberto Pacelli
Prospecting for prostate cancer with precision medicine
Michelle M. Hill, Robert A. Gardiner
Novel therapeutic strategies against cancer and chronic infection by targeting P-selectin glycoprotein ligand-1 as an immune T cells response regulator
Elisa Ramos-Sevillano, Jose Yuste
The immunogenicity of cancer mutations and implications for T cell therapy
Diego Chowell, Timothy A. Chan
CIS is a negative regulator of IL-15-mediated signals in NK cells
Cristina Bottino, Alessandra Dondero, Alessandro Moretta, Roberta Castriconi
An unhealthy diet: making sense of a fatty niche for leukemia stem cells
Sébastien Jacquelin, Emma J. Dishington, Steven W. Lane
Vagus nerve-preserving distal gastrectomy may improve the quality of life after gastrectomy in early stage gastric cancer patients
Souya Nunobe, Takeshi Sano
Glutamine dependence and PIK3CA mutations in colon-rectal cancer cells: ATF4 enters the stage
Nicola Giuliani, Martina Chiu, Marina Bolzoni, Ovidio Bussolati
Is there any role for liver resection in the treatment of liver metastases from gastric carcinoma?
Nathan Grimes, Graeme Poston
Malignant pleural mesothelioma: beyond the mathematical models
Giovanni Leuzzi, Leonardo Duranti, Filippo Lococo
Phenotype: the result of a complex and still largely unknown interplay between molecules
Maria Maddalena Simile, Diego Francesco Calvisi, Gavinella Latte, Franceasco Feo, Rosa Maria Pascale
S-1: changing the facets of adjuvant chemotherapy in pancreatic cancer?
Lukas Perkhofer, Thomas J. Ettrich, Alexander Kleger
Breast cancer following childhood cancer—more to the story than we thought
Daniel A. Mulrooney
Should pertuzumab be used as part of neoadjuvant treatment prior to the release of the APHINITY trial results?
Tom Wei-Wu Chen, Ching-Hung Lin, Chiun-Sheng Huang
MicroRNA master regulator of hematopoiesis may also hold the key to B-cell lymphoma pathogenesis and therapy
Charles H. Lawrie
Comparison of quantitative faecal immunochemical tests for haemoglobin (FIT) for asymptomatic population screening
Callum G. Fraser
Targeting the ubiquitin proteasome system in glioblastoma
Matthew K. Summers, Monica Venere
Radioprotective properties of myeloid-derived suppressor cells
Darren R. Cullinan, James C. Cripe, William G. Hawkins, S. Peter Goedegebuure