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The association between expression of hypoxia inducible factor-1α and multi-drug resistance of acute myeloid leukemia

  
@article{TCR11945,
	author = {Peipei Xu and Miao Wang and Ying Jiang and Jian Ouyang and Bing Chen},
	title = {The association between expression of hypoxia inducible factor-1α and multi-drug resistance of acute myeloid leukemia},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {1},
	year = {2017},
	keywords = {},
	abstract = {Background: Acute myeloid leukemia (AML) is the most common acute leukemia in adults, and chemotherapy is the main treatment. However, patients with AML poorly respond to chemotherapy because of multi-drug resistance (MDR); MDR may mainly involve hypoxia. 
Methods: To investigate the expression levels of hypoxia inducible factor-1α (HIF-1α), MDR1, multi-drug resistant associate protein (MRP), breast cancer resistance protein (BCRP), and lung resistance-associated protein (LRP) in MDR of AML, we detected the blood of 118 patients with AML and 20 healthy people through quantitative real-time polymerase chain reaction (PCR). Data were statistically analyzed in SPSS v12.0 (SPSS Inc., Chicago, IL, USA).
Results: In these hypoxia-induced genes, HIF-1α could be significantly correlated with (P},
	issn = {2219-6803},	url = {http://tcr.amegroups.com/article/view/11945}
}