%0 Journal Article %T Brigatinib and the new generation of ALK-inhibitors for non-small cell lung cancer %A McCall, Neal S. %A Lu, Bo %J Translational Cancer Research %D 2017 %B 2017 %9 %! Brigatinib and the new generation of ALK-inhibitors for non-small cell lung cancer %K %X About 2–7% of non-small cell lung cancer (NSCLC) is driven by the fusion protein between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) (1). The first ALK-inhibitor approved for the treatment of NSCLC was crizotinib with an objective response rate (ORR) up to 74%. Despite this, progression-free survival (PFS) on crizotinib is only 10.9 months, and the cancer invariably recurs with 25–50% of recurrences in the CNS (1,2) ( Table 1 ). Given the protracted natural history of metastatic ALK-rearranged NSCLC in the CNS, treatment options aside from those causing significant neurocognitive degeneration, such as whole brain radiotherapy, are limited (10). %U https://tcr.amegroups.org/article/view/12514 %P S380-S383 %@ 2219-6803