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Dividing and conquering the variation among variants in EML4-ALK lung cancer

  
@article{TCR12644,
	author = {Trever G. Bivona},
	title = {Dividing and conquering the variation among variants in  EML4-ALK  lung cancer},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {2},
	year = {2017},
	keywords = {},
	abstract = {Activating gene rearrangements in the anaplastic lymphoma kinase are present in approximately 2–7% of lung adenocarcinomas (ALK + cancers) (1,2). Patients with ALK + lung adenocarcinoma often benefit from treatment with an ALK tyrosine kinase inhibitor (TKI), such as crizotinib, ceritinib, and alectinib (2). However, acquired ALK TKI resistance remains an obstacle to long-term patient survival in patients who do respond to initial therapy and a distinct subset of ALK + patients fails to experience an initial tumor regression, exhibiting intrinsic resistance (2). Identifying the basis of both innate and acquired resistance is essential to improve clinical outcomes.},
	issn = {2219-6803},	url = {http://tcr.amegroups.com/article/view/12644}
}