TY - JOUR AU - Xu, Yun AU - Jiang, Xiping AU - Huang, Yaqing PY - 2017 TI - T-cell immunoglobulin and mucin-domain containing-3 in malignant cancers JF - Translational Cancer Research; Vol 6, No 3 (June 30, 2017): Translational Cancer Research Y2 - 2017 KW - N2 - Immune checkpoints are one of the key factors comprising the extensive network of the human immune system. Immune checkpoints ensure T-cell homeostasis, activation and differentiation. The checkpoint T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) plays an important role in immune system. Tim-3 is a member of TIM family and can negatively regulate T helper 1 (Th1) immunity. A literature search for Tim-3 was performed via PubMed. It is suggested that the overexpression of Tim-3 is correlated with poorer prognosis for multiple cancers. Co-expression of Tim-3 and other immune checkpoints has been revealed. Blockade of Tim-3 exerts antitumor function and may have synergistic activity being alone or combined with anti-PD-1 antibody or chemotherapy. Thus, Tim-3 is a promising target for cancer immunotherapy. UR - https://tcr.amegroups.org/article/view/13557