%0 Journal Article %T Epigenetic mutations and cancer therapy Effectiven(EZH2) %A Segovia, Cristina %A Paramio, Jesús M. %A Martínez-Fernández, Mónica %J Translational Cancer Research %D 2017 %B 2017 %9 %! Epigenetic mutations and cancer therapy Effectiven(EZH2) %K %X Cancer arises as a consequence of accumulating genomic alterations, which affect primarily oncogenes and tumor suppressor genes (TSGs). This condition creates a particular landmark that can be exploited in therapy. Not surprisingly, many pharma companies launched programs aimed to inhibit the gain of function activities caused by oncogene mutation and/or amplification, and many of these inhibitors are currently in the clinics. The situation is not so simple in the case of TSGs, where a common loss of function precludes, in most cases, their actual use as therapeutic targets. %U https://tcr.amegroups.org/article/view/13589 %P S629-S634 %@ 2219-6803