@article{TCR13855,
author = {Ke Han and Haitang Yang and Liwen Fan and Heng Zhao},
title = {Outcomes of patients with large cell neuroendocrine carcinoma of the lung after complete resection},
journal = {Translational Cancer Research},
volume = {6},
number = {3},
year = {2017},
keywords = {},
abstract = {Background: Large cell neuroendocrine carcinoma (LCNEC) of the lung is a relatively uncommon, aggressive, and preoperatively difficult-to-diagnosis malignancy. Treatment outcomes have not been extensively investigated.
Methods: A cohort of 90 patients who underwent surgical resection and systematic nodal dissection for LCNEC between 2008 and 2014 at a single institution was retrospectively reviewed.
Results: The 90 patients included 80 males and 10 females, with an average age of 62 years. The median survival was 34 months. The 5-year overall survival (OS) and disease-free survival (DFS) were 36.3% and 32.2%, respectively. Multivariate analyses using Cox’s proportional hazards models showed that smoking history [no vs. yes, hazards ratio (HR) =0.390; 95% confidence interval (CI): 0.182–0.835; P=0.015], pathological stage (stage I vs. stage III, HR =0.098, 95% CI: 0.043–0.221; P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/13855}
}