%0 Journal Article %T Vitamin D receptor and cyclooxygenase-2 expression in uterine leiomyoma tissues and their correlation %A Liu, Fujun %A Zhang, Xiao %A Yan, Keqin %A Liang, Jing %A Deng, Lin %A Feng, Dingqing %A Ling, Bin %J Translational Cancer Research %D 2018 %B 2018 %9 %! Vitamin D receptor and cyclooxygenase-2 expression in uterine leiomyoma tissues and their correlation %K %X Background: To explore vitamin D receptor (VDR) and cyclooxygenase-2 (COX-2) expression in uterine leiomyomas and normal myometrium tissues, and further analyze their correlation in the etiopathogenesis of uterine leiomyomas. Methods: We collected uterine leiomyoma tissues and their paired adjacent normal myometrium tissues from 20 cases of uterine leiomyomas and examined the expression of VDR and COX-2 in the tissues by real-time polymerase chain reaction and Western blotting, respectively. We further analyzed the correlation between VDR and COX-2 as well as their expressions with correlation to the size of uterine leiomyomas. Results: The expression of VDR mRNA in 15 of 20 uterine leiomyoma tissues decreased compared with the healthy uterine smooth muscle tissues (P 0.05 for transcriptional level; r=−0.165, P>0.05 for protein level). There was not significant correlation between VDR expression and uterine leiomyoma size, as well as between COX-2 expression and uterine leiomyoma size (r=−0.008, P>0.05; r=0.150, P>0.05, respectively). Conclusions: VDR expression decreased and COX-2 expression increased in uterine leiomyomas compared with the healthy uterine smooth muscles. Decreased VDR expression and high COX-2 expression may play a role in the etiopathogenesis of uterine leiomyomas. There may be a negative relevance between VDR and COX-2 in leiomyomas. %U https://tcr.amegroups.org/article/view/18678 %V 7 %N 1 %P 135-141 %@ 2219-6803