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Evolutionary acquired robustness and vulnerability in cancer genome: negligible negative selection in carcinogenesis

  
@article{TCR19879,
	author = {Kazuki Kumada and Jun Yasuda},
	title = {Evolutionary acquired robustness and vulnerability in cancer genome: negligible negative selection in carcinogenesis},
	journal = {Translational Cancer Research},
	volume = {7},
	number = {Suppl 4},
	year = {2018},
	keywords = {},
	abstract = {Cancer is a disease involving the accumulation of somatic genetic alterations accompanied by clonal evolution (1,2). A wide range of oncogenes and tumor suppressor genes are known to be mutated, deleted, rearranged, and/or amplified in most cancers. These genes have been identified by functional analyses (transformation of NIH3T3), genetic linkage analyses, and structural genomic analyses such as cytogenetics.},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/19879}
}