%0 Journal Article %T Evolutionary acquired robustness and vulnerability in cancer genome: negligible negative selection in carcinogenesis %A Kumada, Kazuki %A Yasuda, Jun %J Translational Cancer Research %D 2018 %B 2018 %9 %! Evolutionary acquired robustness and vulnerability in cancer genome: negligible negative selection in carcinogenesis %K %X Cancer is a disease involving the accumulation of somatic genetic alterations accompanied by clonal evolution (1,2). A wide range of oncogenes and tumor suppressor genes are known to be mutated, deleted, rearranged, and/or amplified in most cancers. These genes have been identified by functional analyses (transformation of NIH3T3), genetic linkage analyses, and structural genomic analyses such as cytogenetics. %U https://tcr.amegroups.org/article/view/19879 %P S445-S448 %@ 2219-6803