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Galectin-9 as a prognostic biomarker in small cell lung cancer

  
@article{TCR21680,
	author = {Yaolin Xu and Chao Guan and Xiaoye Zhang},
	title = {Galectin-9 as a prognostic biomarker in small cell lung cancer},
	journal = {Translational Cancer Research},
	volume = {7},
	number = {3},
	year = {2018},
	keywords = {},
	abstract = {Background: Galectin-9 has been reported to play an important role in the immunoregulation, survival, and growth of different cancers. Our study aims to uncover the clinical significance of galectin-9 in small cell lung cancer (SCLC) postoperatively.
Methods: We studied 48 patients with SCLC who underwent surgery from 2008 to 2014. Galectin-9 expression was assessed by immunohistochemistry on tissue and plot survival curves by the Kaplan-Meier curve. Prognostic analysis was conducted via integrating all of the independent indicators into a multivariate Cox analysis for overall survival (OS). Furthermore, we evaluate whether SCLC patients with high or low galectin-9 expression might benefit from chemotherapy or radiotherapy.
Results: High galectin-9 expression was significantly correlated with high levels of neuron specific enolase (NSE) expression (P=0.04). We found that galectin-9 (P},
	issn = {2219-6803},	url = {http://tcr.amegroups.com/article/view/21680}
}