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Androgen deprivation therapy and radiation therapy for prostate cancer: the mechanism underlying therapeutic synergy

  
@article{TCR22080,
	author = {Catherine S. Spina},
	title = {Androgen deprivation therapy and radiation therapy for prostate cancer: the mechanism underlying therapeutic synergy},
	journal = {Translational Cancer Research},
	volume = {7},
	number = {6},
	year = {2018},
	keywords = {},
	abstract = {The first report of modulation of androgens in men with prostate cancer was conducted by Huggins and Hodges in 1941 (1). In a cohort of 8 men with metastatic prostate cancer including osseous metastases, administration of estradiol and/or surgical castration resulted in a durable reduction of alkaline phosphate levels, a marker of osseous disease burden. By surgically eliminating testicular production of testosterone or negatively regulating the hypothalamic-pituitary-gonadal axis through estrogen administration, this was the first demonstration that androgen suppression can induce a measurable biochemical disease response.},
	issn = {2219-6803},	url = {http://tcr.amegroups.com/article/view/22080}
}