TY - JOUR AU - Wan, Guang-Lun AU - Chen, Hui AU - Zhou, Liang AU - Huang, Jia-Meng PY - 2018 TI - Overexpressed miR-128a inhibits the proliferation of laryngeal cancer cells JF - Translational Cancer Research; Vol 7, No 4 (August 31, 2018): Translational Cancer Research Y2 - 2018 KW - N2 - Background: To identify the expression of miR-128a in laryngeal tumor tissues and to clarify the function of this miR on the proliferation capability of laryngeal cancer cells. Methods: Forty pairs of laryngeal tumor and normal tissue were collected and subjected to quantitative PCR analysis. MiR-128a was overexpressed using lentiviral transfection, and the function of miR-128a was evaluated by proliferation assay, colony formation and apoptosis assay. Tumorigenesis assay was performed in vivo . Results: MiR-128a expression was lower in laryngeal tumor samples. MiR-128a overexpression cells exhibited reduced proliferation, presented enhanced apoptosis, while the reduced tumor formation was observed in miR-128a overexpression cells. Conclusions: MiR-128a suppressed proliferative capability of laryngeal cancer cells and promoted apoptosis in vitro and in vivo . UR - https://tcr.amegroups.org/article/view/22550