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Risk factors and prediction of postoperative hypoparathyroidism among patients with papillary thyroid carcinoma

  
@article{TCR27272,
	author = {Shi-Hang Xue and Zhi-Yu Li and Wei-Zhu Wu},
	title = {Risk factors and prediction of postoperative hypoparathyroidism among patients with papillary thyroid carcinoma},
	journal = {Translational Cancer Research},
	volume = {8},
	number = {2},
	year = {2019},
	keywords = {},
	abstract = {Background: We aimed to study the incidence rate of hypoparathyroidism, its risk factors, and identify its predictive factors among patients with papillary thyroid carcinoma (PTC) who had undergone total or  near-total thyroidectomy and central neck dissection (CND). 
Methods: Ninety-three PTC patients who had undergone total or near-total thyroidectomy and CND were analyzed for hypoparathyroidism. The association between clinicopathological factors and hypoparathyroidism was tested by χ2 test and multivariate logistic regression. The ROC curve and a  2×2 contingency table were used to evaluate the performance of postoperative parathyroid hormone (PTH) and serum calcium concentration in prediction of hypothyroidism. 
Results: Hypothyroidism was observed in 46 patients (49.5%), among whom 2 had permanent hypothyroidism. Univariate analysis showed that tumor size (P=0.034), extraglandular invasion (P=0.028), bilateral tumors (P=0.045), and bilateral CND (P=0.028) were significant risk factors of hypothyroidism. Multivariate analysis showed that extraglandular invasion (P=0.003) and bilateral CND (P=0.044) were independent risk factors. The patients with hypothyroidism had an average PTH level of 8.51 ng/L on the first day after surgery, and those without, 21.39 ng/L (P},
	issn = {2219-6803},	url = {http://tcr.amegroups.com/article/view/27272}
}