%0 Journal Article %T Microarray-based differential expression profiling of long noncoding RNAs and messenger RNAs in formalin-fixed paraffin-embedded human papillary thyroid carcinoma samples %A Yan, Hui-Xian %A Du, Jin %A Fu, Jing %A Huang, Wei %A Jia, Li-Meng %A Ping, Pang %A Zhao, Ling %A Song, Ye-Qiong %A Jia, Xiao-Meng %A Dou, Jing-Tao %A Mu, Yi-Ming %A Wang, Fu-Lin %A Tian, Wen %A Lyu, Zhao-Hui %J Translational Cancer Research %D 2019 %B 2019 %9 %! Microarray-based differential expression profiling of long noncoding RNAs and messenger RNAs in formalin-fixed paraffin-embedded human papillary thyroid carcinoma samples %K %X Background: Long noncoding RNAs (lncRNAs) can regulate the expression of genes at almost every level. The altered expression of lncRNAs was observed in many kinds of cancers. Until recently, few studies have focused on the function of lncRNAs in the context of papillary thyroid carcinoma (PTC). Methods: In the current study, we collected seven PTC and nodular goiter tissue samples and explored mRNA and lncRNA expression patterns in these samples by microarray. Results: We observed aberrant expression of 94 lncRNAs and 99 mRNAs in the seven PTC samples as compared to the nodular goiter tissue [fold change (FC) ≥2.0; P Conclusions: In the present study a string of novel lncRNAs associated with PTC were identified. Further study of these lncRNAs should be performed to identify novel target molecules which may improve diagnosis and treatment of PTC. %U https://tcr.amegroups.org/article/view/27752 %V 8 %N 2 %P 439-451 %@ 2219-6803