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The high expression of TNF-α and NF-κB in tumor microenvironment predicts good prognosis of patients with BCLC-0-B hepatocellular carcinoma

  
@article{TCR28013,
	author = {Haoran Li and Yanhua Wang and Mao Zhang and Jie Hu and Zixiang Li and Bing Han},
	title = {The high expression of TNF-α and NF-κB in tumor microenvironment predicts good prognosis of patients with BCLC-0-B hepatocellular carcinoma},
	journal = {Translational Cancer Research},
	volume = {8},
	number = {2},
	year = {2019},
	keywords = {},
	abstract = {Background: In hepatocellular carcinoma (HCC), inflammatory factors play an important role, but their effects on the prognosis of patients with HCC are still not very clear. 
Methods: Immunohistochemical staining was used to detect the expression of tumor necrosis factor-alpha (TNF-α) and nuclear factor-kappa B (NF-κB) in tumour tissues of Barcelona Clinic Liver Cancer-0-B stage (BCLC-0-B) patients with HCC. The relationship between TNF-α and NF-κB expression and clinicopathological features was analysed by χ2 test. Kaplan-Meier analysis and the log-rank test were used to compare the prognoses of TNF-α and NF-κB high and low-expression groups among HCC patients. The Cox proportional hazard model was used to analyse HCC prognosis by univariate and multivariate analysis. 
Results: Patients with HCC had significantly longer survival times in the TNF-α/NF-κB high-coexpression group (P},
	issn = {2219-6803},	url = {http://tcr.amegroups.com/article/view/28013}
}