%0 Journal Article %T The high expression of TNF-α and NF-κB in tumor microenvironment predicts good prognosis of patients with BCLC-0-B hepatocellular carcinoma %A Li, Haoran %A Wang, Yanhua %A Zhang, Mao %A Hu, Jie %A Li, Zixiang %A Han, Bing %J Translational Cancer Research %D 2019 %B 2019 %9 %! The high expression of TNF-α and NF-κB in tumor microenvironment predicts good prognosis of patients with BCLC-0-B hepatocellular carcinoma %K %X Background: In hepatocellular carcinoma (HCC), inflammatory factors play an important role, but their effects on the prognosis of patients with HCC are still not very clear. Methods: Immunohistochemical staining was used to detect the expression of tumor necrosis factor-alpha (TNF-α) and nuclear factor-kappa B (NF-κB) in tumour tissues of Barcelona Clinic Liver Cancer-0-B stage (BCLC-0-B) patients with HCC. The relationship between TNF-α and NF-κB expression and clinicopathological features was analysed by χ 2 test. Kaplan-Meier analysis and the log-rank test were used to compare the prognoses of TNF-α and NF-κB high and low-expression groups among HCC patients. The Cox proportional hazard model was used to analyse HCC prognosis by univariate and multivariate analysis. Results: Patients with HCC had significantly longer survival times in the TNF-α/NF-κB high-coexpression group (P Conclusions: High expression of TNF-α and NF-κB in the HCC microenvironment can predict survival, and patients with high expression have longer survival times and slowing the recurrence time than those in the low-expression group. %U https://tcr.amegroups.org/article/view/28013 %V 8 %N 2 %P 532-541 %@ 2219-6803