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Neoadjuvant anti-PD-1 immunotherapy for recurrent glioblastoma

	author = {Dana Mitchell and Mahua Dey},
	title = {Neoadjuvant anti-PD-1 immunotherapy for recurrent glioblastoma},
	journal = {Translational Cancer Research},
	volume = {8},
	number = {6},
	year = {2019},
	keywords = {},
	abstract = {In a healthy host, the programmed cell death (PD) pathway serves to regulate T cell activity in order to prevent damage secondary to chronic inflammation and the development of autoimmunity. This pathway is often exploited by human cancers to suppress infiltrating cytotoxic T lymphocytes (CTLs) and evade the anti-tumor immune response (1). Cancers, including glioblastoma (GBM), upregulate the expression of PD-L1, which upon binding to PD-1 expressed on the surface of T cells, results in the attenuation of T cell activity (2). The resulting attenuation of the anti-tumor T cell response is achieved through the suppression of T cell proliferation and cytokine release as well as the induction of T cell anergy, promotion of T cell apoptosis and expansion of the regulatory T cell (Tregs) population (1,2).},
	issn = {2219-6803},	url = {}