@article{TCR29340,
author = {Ning Xu and Yu-Peng Wu and Zhi-Bin Ke and Ying-Chun Liang and Xuan Tao and Shao-Hao Chen and Xiao-Dong Li and Hai Cai and Yun-Zhi Lin and Ting-Ting Lin and Xue-Yi Xue},
title = {Risk factors of developing visceral metastases at diagnosis in prostate cancer patients},
journal = {Translational Cancer Research},
volume = {8},
number = {3},
year = {2019},
keywords = {},
abstract = {Background: Risk factors of visceral metastases in prostate cancer (PCa) patients are unclear. The aim of this study is to investigate the risk factors of developing visceral metastases at diagnosis and the impact of these risk factors on the survival of patients with visceral metastatic PCa.
Methods: Patients with visceral metastases at the time of diagnosis of [2010–2015] PCa were identified using the Surveillance, Epidemiology, and End Results (SEER) database. Visceral metastatic distribution data were provided for liver, lung, and brain. The overall survival (OS) was calculated by the Kaplan-Meier method. Multivariable logistic and Cox regression models were performed to identify risk factors and analyze survival outcomes.
Results: A total of 13,092 eligible patients with stage IV PCa were identified from SEER database. A total of 598 patients developed visceral metastases at diagnosis among these patients. In multivariable analyses, patients with PSA >80 ng/mL had 1.545-fold higher risk of developing visceral metastases compared with those with PSA },
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/29340}
}