@article{TCR29795,
author = {Jong Y. Park and Hung N. Luu and Hyun Y. Park and Hui-Yi Lin and Selina Radlein and Giuliano Di Pietro and Chang Dong Yeo and Seung Joon Kim and Nahyeon Kang and Samuel Antwi and Wade J. Sexton and Philippe E. Spiess and Shohreh Dickinson and Alexander Parker},
title = {Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma},
journal = {Translational Cancer Research},
volume = {8},
number = {Suppl 4},
year = {2019},
keywords = {},
abstract = {Background: Telomeres are essential for chromosomal stability and may play a key role in carcinogenesis. Telomere length is suggested as a tentative biomarker of risk for renal cell carcinoma (RCC). However, results of previous association studies between telomere length and risk for RCC are inconsistent.
Methods: We evaluated RCC risk in relation to peripheral blood leukocyte telomere length using a hospital-based case–control study of 169 RCC cases and 189 controls. Cases were histologically-confirmed RCC patients who were treated at the Moffitt Cancer Center (Tampa, FL). Controls with no history of cancer underwent a screening exam at the Lifetime Cancer Screening Center at Moffitt Cancer Center to rule out the presence of cancer. Relative telomere length (RTL) was measured by quantitative real-time polymerase chain reaction (PCR) using peripheral blood leukocyte DNA. Logistic regression was used to determine the association between RTL and RCC risk.
Results: As expected, increasing age was inversely correlated with RTL (Pearson r=−0.213, P=0.003) among controls but not cases. Average RTL was significantly shorter in cases as compared with controls [mean ± standard deviation (SD): 3.18±1.50 and 4.39±1.99, respectively, P},
issn = {2219-6803}, url = {https://tcr.amegroups.org/article/view/29795}
}