TY - JOUR AU - Park, Jong Y. AU - Luu, Hung N. AU - Park, Hyun Y. AU - Lin, Hui-Yi AU - Radlein, Selina AU - Di Pietro, Giuliano AU - Yeo, Chang Dong AU - Kim, Seung Joon AU - Kang, Nahyeon AU - Antwi, Samuel AU - Sexton, Wade J. AU - Spiess, Philippe E. AU - Dickinson, Shohreh AU - Parker, Alexander PY - 2019 TI - Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma JF - Translational Cancer Research; Vol 8, Supplement 4 (July 29, 2019): Translational Cancer Research (Population Science in Cancer) Y2 - 2019 KW - N2 - Background: Telomeres are essential for chromosomal stability and may play a key role in carcinogenesis. Telomere length is suggested as a tentative biomarker of risk for renal cell carcinoma (RCC). However, results of previous association studies between telomere length and risk for RCC are inconsistent. Methods: We evaluated RCC risk in relation to peripheral blood leukocyte telomere length using a hospital-based case–control study of 169 RCC cases and 189 controls. Cases were histologically-confirmed RCC patients who were treated at the Moffitt Cancer Center (Tampa, FL). Controls with no history of cancer underwent a screening exam at the Lifetime Cancer Screening Center at Moffitt Cancer Center to rule out the presence of cancer. Relative telomere length (RTL) was measured by quantitative real-time polymerase chain reaction (PCR) using peripheral blood leukocyte DNA. Logistic regression was used to determine the association between RTL and RCC risk. Results: As expected, increasing age was inversely correlated with RTL (Pearson r=−0.213, P=0.003) among controls but not cases. Average RTL was significantly shorter in cases as compared with controls [mean ± standard deviation (SD): 3.18±1.50 and 4.39±1.99, respectively, P Conclusions: We found that shorter RTL is associated with an increased risk for RCC. Our findings suggest that telomere length may be involved in the development of RCC. UR - https://tcr.amegroups.org/article/view/29795