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miR-486 as an unfavorable prognostic biomarker for patients with non-small cell lung cancer

  
@article{TCR33496,
	author = {Zhao-Jia Gao and Wei-Dong Yuan and Jun-Qiang Yuan and Kai Yuan and Yong Wang},
	title = {miR-486 as an unfavorable prognostic biomarker for patients with non-small cell lung cancer},
	journal = {Translational Cancer Research},
	volume = {9},
	number = {1},
	year = {2019},
	keywords = {},
	abstract = {Background: Non-small cell lung cancer (NSCLC) is the most common malignant tumor in China. miR- 486 was found to be associated with many tumors. In previous study, we aimed to investigate the expression and prognostic value of miR-486 in patients with NSCLC.
Methods: In order to measure the expression of miR-486 in 140 NSCLC patients, in situ hybridization (ISH) was made. The staining of miR-486 was scored by two independent investigators. Then, the prognostic value of miR-486 was evaluated by plotting Kaplan-Meier survival curves and making multivariate analysis.
Results: miR-486 was mainly expressed in the cytoplasm of tumor cells. miR-486 expression was corrected with tumor differentiation (P=0.011) but not with any other clinicopathological characteristics. However, high expression of miR-486 was significantly correlated with shortened overall survival (OS) in NSCLC patients (P=0.001), especially in stage I patients (P=0.005). Multivariate analysis revealed that miR-486 was an independent prognostic factor in NSCLC patients (P=0.002).
Conclusions: miR-486 high expression predicts poor survival in patients with NSCLC. miR-486 could be used as an unfavorable prognostic biomarker for NSCLC patients.},
	issn = {2219-6803},	url = {http://tcr.amegroups.com/article/view/33496}
}