TY - JOUR AU - Gao, Zhao-Jia AU - Yuan, Wei-Dong AU - Yuan, Jun-Qiang AU - Yuan, Kai AU - Wang, Yong PY - 2019 TI - miR-486 as an unfavorable prognostic biomarker for patients with non-small cell lung cancer JF - Translational Cancer Research; Vol 9, No 1 (January 18, 2020): Translational Cancer Research Y2 - 2019 KW - N2 - Background: Non-small cell lung cancer (NSCLC) is the most common malignant tumor in China. miR- 486 was found to be associated with many tumors. In previous study, we aimed to investigate the expression and prognostic value of miR-486 in patients with NSCLC. Methods: In order to measure the expression of miR-486 in 140 NSCLC patients, in situ hybridization (ISH) was made. The staining of miR-486 was scored by two independent investigators. Then, the prognostic value of miR-486 was evaluated by plotting Kaplan-Meier survival curves and making multivariate analysis. Results: miR-486 was mainly expressed in the cytoplasm of tumor cells. miR-486 expression was corrected with tumor differentiation (P=0.011) but not with any other clinicopathological characteristics. However, high expression of miR-486 was significantly correlated with shortened overall survival (OS) in NSCLC patients (P=0.001), especially in stage I patients (P=0.005). Multivariate analysis revealed that miR-486 was an independent prognostic factor in NSCLC patients (P=0.002). Conclusions: miR-486 high expression predicts poor survival in patients with NSCLC. miR-486 could be used as an unfavorable prognostic biomarker for NSCLC patients. UR - https://tcr.amegroups.org/article/view/33496