%0 Journal Article
%T Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
%A Mazur, Pawel K.
%A Gozani, Or
%A Sage, Julien
%A Reynoird, Nicolas
%J Translational Cancer Research
%D 2016
%B 2016
%9 
%! Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
%K 
%X SMYD3 is a member of the SMYD family of lysine methyltransferases (KMTs). In humans, there are five SMYD members (SMYD1–5) that are characterized by the presence of a split catalytic SET domain interrupted by a MYND zinc finger domain. The MYND domain is thought to potentially mediate DNA or protein binding but a clear function is yet to be established. SMYD homologs have been described in a wide range of organisms, such as zebrafish, drosophila and budding yeast (1,2). While methylation activity has been clearly established for SMYD2 and SMYD3 (3-6), the activities of SMYD1, 4 and 5 are not well understood.
%U https://tcr.amegroups.org/article/view/8176
%V 5
%N 3
%P 330-333
%@ 2219-6803