Yu Shyr, PhD

Professor of Biostatistics, Biomedical Informatics, and Health Policy, Vanderbilt University Medical Center, Nashville, TN, USA

Dr. Yu Shyr received his PhD in biostatistics from the University of Michigan (Ann Arbor) in 1994 and subsequently joined the faculty at Vanderbilt University School of Medicine. At Vanderbilt, he has collaborated on numerous research projects; assisted investigators in developing clinical research protocols; collaborated on multiple grants funded through external peer-reviewed mechanisms; and developed biostatistical and bioinformatic methodologies for clinical trial design, high-dimensional data analysis, and experimental design.

Dr. Shyr is a Fellow of the American Statistical Association (ASA), an elected fellow of the American Association for the Advancement of Science (AAAS) and a US Food and Drug Administration (FDA) advisory committee voting member. He has published more than 450 peer-reviewed papers in a variety of journals (h-index = 90), such as Nature, NEJM, JAMA, Cell, Lancet, Nature Medicine, Nature Protocols, JAMA Oncology, JCI, Bioinformatics, BMC Bioinformatics, Clinical Trials, Statistics in Medicine, Biometrics, Statistical Applications in Genetics and Molecular Biology, and Computational Statistics and Data Analysis.  He was the member of the US National Academy of Medicine (IOM) Committee on Policy Issues in the Clinical Development of Biomarkers for Molecularly Targeted Therapies. He has served as a member of the US National Cancer Institute (NCI) Developmental Therapeutics Study Section, Cancer Immunopathology and Immunotherapy Study Section and the Population and Patient-oriented Training Study Section. Dr. Shyr has presented as an invited faculty member in the ASCO Educational Section on Advanced Concepts in Clinical Trial Design and Methodology and he was the co-course director for the AACR/ASCO Methods in Clinical Cancer Research Vail Workshop. In addition to this, he has prepared statistical workshops worldwide and presented them in countries, such as, Belgium, Canada, France, the Netherlands, Germany, Austria, China, Japan, Singapore, Saudi Arabia, Malaysia, Taiwan, and Hong Kong. He currently serves on 15 external advisory boards for institutions including Yale University, Northwestern University, Dartmouth College, UT Southwestern, OHSU, University of Colorado, and Moffitt Cancer Center; is a member of the editorial board for the Journal of Clinical Oncology, JNCI, Clinical Cancer Research, Cancer and Cancer Prevention Research Journal as well as ASCO’s Cancer Research Committee; and directs the biostatistics and bioinformatics cores for the NCI-funded Vanderbilt University Breast Cancer SPORE, GI Cancer SPORE, and other program projects. He is the Associate Editor for JAMA Oncology, Journal of Thoracic Oncology (JTO), and the Statistical Advisory Board Member for PLoS ONE. In addition, Dr. Shyr is the principle investigator of the NCI U01 grant of Barrett’s esophagus translational research network coordinating center (BETRNetCC). Dr. Shyr’s current research interests focus on developing statistical bioinformatic methods for analyzing next-generation sequencing data based on single cell technology including a series of papers on estimating the sample size requirements for studies conducting DNA and RNA sequencing analysis.