Oncogenic insult to the brain: sox proteins rise to the occasion

Hannah M. Wüst, Michael Wegner


The concept of cancer stem or stem-like cells has changed thinking and approaches in oncology just as much as the discovery of stem cells did in developmental biology and regenerative medicine before. Glioblastoma multiforme (GBM) as the most frequent and malignant primary brain tumor with an extremely poor prognosis is a case in point (1).

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