Editorial: fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

Sabrina P. Koh, Agadha C. Wickremesekera, Tinte Itinteang, Swee T. Tan

Abstract

Glioblastoma (GB) is the most aggressive primary brain cancer of adulthood, associated with an average 5-year survival rate of 2% (1). A small population of tumor-initiating cells, termed cancer stem cells (CSCs), are the putative origin of GB, accounting for tumor development, progression and recurrence (2).