Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components

Brandon J. Manley, James J. Hsieh


The estimated new kidney cancer cases diagnosed each year in the United Sates and in the world are ~63,000 and ~300,000, respectively (1,2). Renal cell carcinoma (RCC) represents over 90% of kidney cancer and consists of a group of malignancies arising from the renal epithelium and exhibiting distinct histopathological features (3-6). The 2004 WHO classification listed 12 different subtypes of RCC (4). With a better understanding of the molecular pathogenesis of RCC, the 2013 International Society of Urological Pathology (ISUP) consensus conference added several new entities (6).