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Neuroendocrine differentiation in prostate cancer: key epigenetic players

   
@article{TCR11869,
	author = {Karishma Gupta and Sanjay Gupta},
	title = {Neuroendocrine differentiation in prostate cancer: key epigenetic players},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {Suppl 1},
	year = {2017},
	keywords = {},
	abstract = {A recent publication by Dardenne et al. (1) in Cancer Cell (October 10, Vol. 30: 563–577, 2016) demonstrate N-Myc overexpression and its stabilization by Aurora-A (AURKA) and AKT1 Kinase induces enhancer of zeste homolog 2 (EZH2)-mediated transcriptional reprogramming repressing androgen receptor (AR) and driving neuroendocrine prostate cancer (1). This has important clinical implication proposing combinatorial therapy using inhibitors of phosphatidylinositol 3-kinase (PI3K)-AKT and AURKA as future trials in the management of neuroendocrine tumors.},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/11869}
}