%0 Journal Article %T Neuroendocrine differentiation in prostate cancer: key epigenetic players %A Gupta, Karishma %A Gupta, Sanjay %J Translational Cancer Research %D 2017 %B 2017 %9 %! Neuroendocrine differentiation in prostate cancer: key epigenetic players %K %X A recent publication by Dardenne et al . (1) in Cancer Cell (October 10, Vol. 30: 563–577, 2016) demonstrate N-Myc overexpression and its stabilization by Aurora-A (AURKA) and AKT1 Kinase induces enhancer of zeste homolog 2 (EZH2)-mediated transcriptional reprogramming repressing androgen receptor (AR) and driving neuroendocrine prostate cancer (1). This has important clinical implication proposing combinatorial therapy using inhibitors of phosphatidylinositol 3-kinase (PI3K)-AKT and AURKA as future trials in the management of neuroendocrine tumors. %U https://tcr.amegroups.org/article/view/11869 %P S104-S108 %@ 2219-6803