TY - JOUR AU - Gupta, Karishma AU - Gupta, Sanjay PY - 2017 TI - Neuroendocrine differentiation in prostate cancer: key epigenetic players JF - Translational Cancer Research; Vol 6, Supplement 1 (February 28, 2017): Translational Cancer Research Y2 - 2017 KW - N2 - A recent publication by Dardenne et al . (1) in Cancer Cell (October 10, Vol. 30: 563–577, 2016) demonstrate N-Myc overexpression and its stabilization by Aurora-A (AURKA) and AKT1 Kinase induces enhancer of zeste homolog 2 (EZH2)-mediated transcriptional reprogramming repressing androgen receptor (AR) and driving neuroendocrine prostate cancer (1). This has important clinical implication proposing combinatorial therapy using inhibitors of phosphatidylinositol 3-kinase (PI3K)-AKT and AURKA as future trials in the management of neuroendocrine tumors. UR - https://tcr.amegroups.org/article/view/11869