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Immunotherapy’s new challenge: identification of predictive biomarkers for tumor response

   
@article{TCR12602,
	author = {Charlotte Domblides and Anne-Marie Ruppert and Martine Antoine and Marie Wislez},
	title = {Immunotherapy’s new challenge: identification of predictive biomarkers for tumor response},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {Suppl 2},
	year = {2017},
	keywords = {},
	abstract = {Immune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1)/ programmed cell death protein ligand 1 (PD-L1) pathway are a promising therapeutic option in patients with non-small cell lung cancer (NSCLC) (1). However, PD-L1 immunohistochemistry (IHC) assessment has a non-optimal predictive value of response. Main reasons are tumor heterogeneity, no standardized staining assessment with different primary antibodies, variable positive thresholds and interobserver variability. A major challenge for these immunotherapies is to improve patient selection. PD-L1 expression does not seem to be sufficient, and other immunologic or non-immunologic markers may influence responses to ICI.},
	issn = {2219-6803},	url = {https://tcr.amegroups.org/article/view/12602}
}