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Epigenetic mutations and cancer therapy Effectiven(EZH2)

	author = {Cristina Segovia and Jesús M. Paramio and Mónica Martínez-Fernández},
	title = {Epigenetic mutations and cancer therapy Effectiven(EZH2)},
	journal = {Translational Cancer Research},
	volume = {6},
	number = {Suppl 3},
	year = {2017},
	keywords = {},
	abstract = {Cancer arises as a consequence of accumulating genomic alterations, which affect primarily oncogenes and tumor suppressor genes (TSGs). This condition creates a particular landmark that can be exploited in therapy. Not surprisingly, many pharma companies launched programs aimed to inhibit the gain of function activities caused by oncogene mutation and/or amplification, and many of these inhibitors are currently in the clinics. The situation is not so simple in the case of TSGs, where a common loss of function precludes, in most cases, their actual use as therapeutic targets.},
	issn = {2219-6803},	url = {}